Application Note : 012
Title of application :
Detection of Impurities from Purified Terephathalic Acid
Area of application :
Quality assurance/ Petrochemical analysis
Conditions :
| Buffer | TPA-01 (100 mM), pH= 10.5; |
| Sample | Purified terephthalic acid (solid sample); |
| Capillary | 50 mm i.d, 70 cm length; |
| Injection mode | Hydrodynamic injection; |
| Separation setting | + 20 kV |
| Instrument used | CE-L1, UV detection at 200 nm |
Description :
The determination of ppm levels of impurities from a technical product
can be very challenging for any analytical methods, because it requires good performance
with respect to both detection sensitivity and sample capacity.
Here, by formulating the right kind of CZE buffer, the major component, terephthalic acid
was made migrating the last, while all the target impurities were eluted ahead of the
major component with good peak symmetry. As a result, all the impurities could be
separated and measured with satisfactory accuracy. CE-L1 can be applied similarily in a
lot other cases, for purposes of quality assurance as well as product characterization.
Download application sheet in PDF format